MersV1, France, Analysis, bibRecord, 000278

Determination of the human c-Abl consensus DNA binding site

Identifieur interne : 000278 ( France/Analysis ); précédent : 000277; suivant : 000279

Determination of the human c-Abl consensus DNA binding site

Auteurs : Marie-Hélène David-Cordonnier [France] ; Malika Hamdane [France] ; Christian Bailly [France] ; Jean-Claude D'Halluin [France]

Source :

FEBS Letters [ 0014-5793 ] ; 1998.

RBID : ISTEX:DF35ED7E47178F4D89B17D09642A0B6C8CE8266D

English descriptors

Teeft :
- Actin binding site, Anking sequences, Base pairs, Binding activity, Binding capacity, Binding domain, Binding sites, Bold letters, Cell cycle, Clone, Computer programs, Consensus binding site, Consensus sequence, Deletion, Deletion mutants, Dnase, Domain, Feb, Fusion peptide, Fusion protein, Human protein, Kinase, Klenow enzyme, Large domain, Ligue nationale contre, Lille, Mouse protein, Mutant, Protein binding site, Secondary structure, Target site, Threonine residues, Tyrosine, Tyrosine kinase, Wang.

Abstract

Abstract: c-Abl tyrosine kinase, an essential protein of the cell cycle signalling pathways, is implicated in the regulation of RNA polymerase II activity, apoptosis and DNA repair. Its DNA binding activity is important for its biological functions. However, the molecular basis of c-Abl interaction with DNA remains largely unclear. We delimited the human c-Abl DNA binding domain and identified its preferred binding site, 5′-AA/CAACAAA/C. The central AAC motif is highly conserved and constitutes the major core element in the binding sites. EMSAs and footprinting experiments were performed to explore how the c-Abl fusion protein recognizes specific sequences in DNA.

Url:

https://api.istex.fr/ark:/67375/6H6-10DVCWBB-T/fulltext.pdf

DOI: 10.1016/S0014-5793(98)00169-0

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 001059
to stream Istex, to step Curation: 001059
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to stream Main, to step Merge: 003B25
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to stream Main, to step Exploration: 003A76
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Links to Exploration step

ISTEX:DF35ED7E47178F4D89B17D09642A0B6C8CE8266D

Le document en format XML

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Determination of the human c-Abl consensus DNA binding site

Determination of the human c-Abl consensus DNA binding site

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri